BioInnovation Institute Faculty
As of January 2020, BioInnovation Institute has entered a collaboration with The Technical University of Denmark (DTU) to create a unique interdisciplinary environment focused on commercialization that can foster novel ideas and lead to new spin-outs.
From January 2020, the first university projects from DTU will join BII for a three-year period. The university-based projects will establish a team that will work in BII’s office and lab space alongside projects and start-ups in the BII programs.
BII will source the projects and besides fostering new companies, BII expects to see benefits from interdisciplinary collaborations and cross-fertilizations of methods and tools between the projects in all BII programs.
Each project will be granted DKK 6M per year starting in 2020 and BII is committed to supporting the projects through to the end of 2022. BII expects to accept 5-6 projects in BII Faculty in 2020.
Read more about the projects in BII’s Faculty below.
Microbial cell therapies for modulating the gut-brain axis
The gut-brain axis is established with important roles in several debilitating diseases, including depression, anxiety and Parkinson disease. However, limited therapeutic options are available to modulate the gutbrain axis. We created a first microbial cell therapy producing the neuroactive compound serotonin in situ of the gut, which leads to statistically significant changes in behavioral markers of depression and anxiety.
Microbial production of therapeutic alkaloids
Monoterpenoid indole alkaloids (MIAs) are plant-derived natural products with remarkable structural diversity and a myriad of applications as therapeutics, nutraceuticals, pest control agents, colorants, and materials precursors. The project focuses on developing a robust microbial platform for production of any desired MIA, to do the business development to determine the target MIAs that an eventual company will commercialize, and to construct separate yeast hosts that will produce these molecules at high tier, rates and yields.