Faculty - BioInnovation Institute

Faculty

Faculty

Projects
Professor Morten Otto Alexander Sommer

Microbial cell therapies for modulating the gut-brain axis

The gut-brain axis is established with important roles in several debilitating diseases, including depression, anxiety and Parkinson disease. However, limited therapeutic options are available to modulate the gut-brain axis. We are making microbial cell therapies producing the neuroactive compounds in situ of the gut to treat diseases of the central nervous system.

Partners on project:
Principle investigator & project team: Morten Otto Alexander Sommer, Harris Wang, Anders Schou Andersen
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Professor Jay Keasling

Microbial production of therapeutic alkaloids

Monoterpenoid indole alkaloids (MIAs) are plant-derived natural products with remarkable structural diversity and a myriad of applications as therapeutics, nutraceuticals, pest control agents, and materials precursors. The project focuses on three things; developing a robust microbial platform for production of any desired MIA, determining the target MIAs that an eventual company will commercialize, and constructing separate yeast hosts that will produce these molecules at high titers, rates and yields.

Partners on project:
DTU
Principle investigator & project team: Jay D. Keasling, Michael Krogh Jensen, Jie Zhang. C
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Professor Thomas Lars Andresen

Locally Sustained Gene Therapy

Thomas Andresen’s project will use the team’s expertise in image-guided local injections, biomaterials and gene delivery, to create systems that can induce local cell transfection, and use the cells as therapeutic factories to reprogram local tissue microenvironments. Such reprogramming of local tissues has highly impactful treatment possibilities in cancer, autoimmune, and infectious disease.

Partners on project:
Principle investigator & project team: Thomas Lars Andresen, Anders E. Hansen, Ashley Montgomery, Martin Bak, Fredrik Melander, Esben Christensen
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Professor Henriette Svarre Nielsen

Early diagnosis of pregnancy loss

Professor Henriette Svarre Nielsen aims to increase live birth rates by developing a comprehensive diagnostic test that can inform couples after a pregnancy loss. The product combines a test that both diagnoses the fetus and the parents using paternal and maternal biomarkers to guide relevant actions.

Partners on project:
Principle investigator & project team: Henriette Svarre Nielsen, Eva Hoffmann, Jenny Gruhn, Andy Chi Ho Chan, David Westergaard, Tanja Schlaikjær Hartwig, Finn Stener Jørgensen, Astrid Kolte, Signe Breum Blom.
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Professor Anja Boisen

Therapeutic drug monitoring

Professor Anja Boisen is developing a miniaturized tabletop device that can perform therapeutic drug monitoring on a single drop of blood in a matter of minutes. The research group will be working on a solution available at point of care without the need for specialized personnel and at a fraction of the currently available cost.

Partners on project:
Principle investigator & project team: Anja Boisen, Kinga Zor, Tomas Rindzevicius, Sriram T. Rajendran, Laura Serioli, Roman Slipets, En Te Hwu, Lasse Højlund Eklund Thamdrup, Kjeld Schmiegelow, Yaman Göksel.
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